Low-Dose vs Full-Dose Apixaban in VTE: What Does AMPLIFY-EXT Trial Tell Us?

A short review of the AMPLIFY-EXT trial which evaluated the use of apixaban at 2.5 mg BID and 5 mg BID vs placebo for the prophylaxis of VTE after an initial course of anticoagulation

Byclassicalhematology
February 10, 2025

Clinical Trials

Vitamin B12 Deficiency

Review of the most important aspects to consider for the diagnosis and management of vitamin B12 deficiency.

Byclassicalhematology
January 18, 2025

Education

Anemia of Inflammation/Anemia of Chronic Disease

Review of anemia of inflammation including its definition, pathophysiology, the role of hepcidin, diagnosis, and management. A special focus is given at the differential between anemia of inflammation and iron deficiency

Byclassicalhematology
January 13, 2025

Curriculum, Hemoglobin Disorders

Methemoglobinemia

A summary of methemoglobinemia and review its definition, causes, clinical manifestations, and management of both acquired and congenital forms

Byclassicalhematology
November 7, 2024

Curriculum, Hemoglobin Disorders

Less Common Hemoglobin Variants (D, E, O, H)

In this post, we explore the less common hemoglobin variants—D, E, O, and H—highlighting their key characteristics and clinical significance. Additionally, we provide a brief overview of hydrops fetalis

Byclassicalhematology
November 1, 2024

Curriculum, Education, Hemoglobin Disorders

Disorders of Hemoglobin C

We describe the hemoglobin C variants, its clinical manifestations, particularly in hemoglobin C disease, Hb sickle disease, and the management of these conditions

Byclassicalhematology
October 27, 2024

Curriculum, Education

Management of Sickle Cell Disease/Sickle Cell Anemia (SCD/SCA)

Management of sickle cell disease including acute complications (vasoocclusive events, acute chest syndrome, stroke, and others), and long term management including medications, blood products, stem cell transplant, and gene therapy

Byclassicalhematology
October 10, 2024

Curriculum, Education

Sickle Cell Disease (SCD) and Hemoglobin S Disorders

An overview of hemoglobin S disorders including their definitions, epidemiology, classification, diagnosis, and prognosis of these conditions. An introduction to a future review of the management of sickle cell disease

Byclassicalhematology
September 20, 2024

Curriculum, Education

Management of Thalassemias

A summary of the management of thalassemias with emphasis on the management of anemia with transfusion support, iron overload, medications such as luspatercept, and advanced treatments such as stem cell and gene therapy

Byclassicalhematology
September 13, 2024

Curriculum, Education

Overview of Thalassemias

An overview of thalassemias including their definition, classification, and description of the most common thalassemias. We hope to help you understand the differences between alpha and beta thalassemias better!

Byclassicalhematology
August 23, 2024

Curriculum, Education

Iron Deficiency Anemia (IDA)

A review of iron deficiency with and without anemia and their clinical manifestations, diagnosis, management, and monitoring of response. A key topic in hematology!

Byclassicalhematology
November 15, 2024

Curriculum, Education

Causes and Classification of Anemias

Explore the causes and classifications of anemias, from microcytic, normocytic, and macrocytic types. A classification to help you understand the big picture of all anemias!

Byclassicalhematology
May 24, 2024

Curriculum, Education

Overview of Red Blood Cells

An introduction to red blood cells, their anatomy, function, erythropoiesis, RBC lifespan, and classification of red blood cell disorders (anemias and polycythemias)

Byclassicalhematology
August 23, 2024

Curriculum, Education

Platelet Clumping (Pseudothrombocytopenia) Question

Challenge yourself with this interesting clinical case and question of a patient with platelet clumping or pseudothrombocytopenia

Byclassicalhematology
May 11, 2024

Education, Q-Bank

Advanced Hematology Diagnostic Testing

We review advanced tests in hematology including hemoglobin electrophoresis, plasma cell markers, flow cytometry, molecular testing, and some imaging modalities including PET/CT scan, skeletal surveys, and Doppler ultrasonography

Byclassicalhematology
May 10, 2024

Curriculum, Education

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