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Methemoglobinemia
A summary of methemoglobinemia and review its definition, causes, clinical manifestations, and management of both acquired and congenital forms
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Less Common Hemoglobin Variants (D, E, O, H)
In this post, we explore the less common hemoglobin variants—D, E, O, and H—highlighting their key characteristics and clinical significance. Additionally, we provide a brief overview of hydrops fetalis
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Disorders of Hemoglobin C
We describe the hemoglobin C variants, its clinical manifestations, particularly in hemoglobin C disease, Hb sickle disease, and the management of these conditions
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Management of Sickle Cell Disease/Sickle Cell Anemia (SCD/SCA)
Management of sickle cell disease including acute complications (vasoocclusive events, acute chest syndrome, stroke, and others), and long term management including medications, blood products, stem cell transplant, and gene therapy
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Sickle Cell Disease (SCD) and Hemoglobin S Disorders
An overview of hemoglobin S disorders including their definitions, epidemiology, classification, diagnosis, and prognosis of these conditions. An introduction to a future review of the management of sickle cell disease
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Management of Thalassemias
A summary of the management of thalassemias with emphasis on the management of anemia with transfusion support, iron overload, medications such as luspatercept, and advanced treatments such as stem cell and gene therapy
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Overview of Thalassemias
An overview of thalassemias including their definition, classification, and description of the most common thalassemias. We hope to help you understand the differences between alpha and beta thalassemias better!
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Iron Deficiency Anemia (IDA)
A review of iron deficiency with and without anemia and their clinical manifestations, diagnosis, management, and monitoring of response. A key topic in hematology!
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Causes and Classification of Anemias
Explore the causes and classifications of anemias, from microcytic, normocytic, and macrocytic types. A classification to help you understand the big picture of all anemias!
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Overview of Red Blood Cells
An introduction to red blood cells, their anatomy, function, erythropoiesis, RBC lifespan, and classification of red blood cell disorders (anemias and polycythemias)
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Platelet Clumping (Pseudothrombocytopenia) Question
Challenge yourself with this interesting clinical case and question of a patient with platelet clumping or pseudothrombocytopenia
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Advanced Hematology Diagnostic Testing
We review advanced tests in hematology including hemoglobin electrophoresis, plasma cell markers, flow cytometry, molecular testing, and some imaging modalities including PET/CT scan, skeletal surveys, and Doppler ultrasonography
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Bone Marrow Biopsy in Clinical Practice
Learn about the bone marrow examination and its importance in clinical practice. We describe the main considerations to learn about this relevant procedure
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Evaluation of the Peripheral Blood Smear
Learn about the essential equipment, preparation steps, and systematic approach for interpreting peripheral blood smears—a vital clinical diagnostic tool
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Laboratory Assessment in Hematology
A description of the most frequent and important tests performed in hematology for the assessment of patients. A guide for trainees and other healthcare providers.
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