Prognostic Clinical Tools (Risk Stratification) in Lymphomas
An overview of the most frequently used stratification tools in diffuse large B-cell lymphoma (IPI), follicular lymphoma (FLIPI), and mantle cell lymphoma (MIPI)
classicalhematology
Inherited Bone Marrow Failure Syndromes (IBMFS)
An overview of the inherited bone marrow failure syndromes (IBMFs), when to suspect them, and a brief description of the most common IBMFs
Low-Dose vs Full-Dose Apixaban in VTE: What Does AMPLIFY-EXT Trial Tell Us?
A short review of the AMPLIFY-EXT trial which evaluated the use of apixaban at 2.5 mg BID and 5 mg BID vs placebo for the prophylaxis of VTE after an initial course of anticoagulation
Vitamin B12 Deficiency
Review of the most important aspects to consider for the diagnosis and management of vitamin B12 deficiency.
Anemia of Inflammation/Anemia of Chronic Disease
Review of anemia of inflammation including its definition, pathophysiology, the role of hepcidin, diagnosis, and management. A special focus is given at the differential between anemia of inflammation and iron deficiency
Methemoglobinemia
A summary of methemoglobinemia and review its definition, causes, clinical manifestations, and management of both acquired and congenital forms
Less Common Hemoglobin Variants (D, E, O, H)
In this post, we explore the less common hemoglobin variants—D, E, O, and H—highlighting their key characteristics and clinical significance. Additionally, we provide a brief overview of hydrops fetalis
Disorders of Hemoglobin C
We describe the hemoglobin C variants, its clinical manifestations, particularly in hemoglobin C disease, Hb sickle disease, and the management of these conditions
Management of Sickle Cell Disease/Sickle Cell Anemia (SCD/SCA)
Management of sickle cell disease including acute complications (vasoocclusive events, acute chest syndrome, stroke, and others), and long term management including medications, blood products, stem cell transplant, and gene therapy
Sickle Cell Disease (SCD) and Hemoglobin S Disorders
An overview of hemoglobin S disorders including their definitions, epidemiology, classification, diagnosis, and prognosis of these conditions. An introduction to a future review of the management of sickle cell disease
