A short review of the AMPLIFY-EXT trial which evaluated the use of apixaban at 2.5 mg BID and 5 mg BID vs placebo for the prophylaxis of VTE after an initial course of anticoagulation
Review of the most important aspects to consider for the diagnosis and management of vitamin B12 deficiency.
Review of anemia of inflammation including its definition, pathophysiology, the role of hepcidin, diagnosis, and management. A special focus is given at the differential between anemia of inflammation and iron deficiency
A summary of methemoglobinemia and review its definition, causes, clinical manifestations, and management of both acquired and congenital forms
In this post, we explore the less common hemoglobin variants—D, E, O, and H—highlighting their key characteristics and clinical significance. Additionally, we provide a brief overview of hydrops fetalis
We describe the hemoglobin C variants, its clinical manifestations, particularly in hemoglobin C disease, Hb sickle disease, and the management of these conditions
Management of sickle cell disease including acute complications (vasoocclusive events, acute chest syndrome, stroke, and others), and long term management including medications, blood products, stem cell transplant, and gene therapy
An overview of hemoglobin S disorders including their definitions, epidemiology, classification, diagnosis, and prognosis of these conditions. An introduction to a future review of the management of sickle cell disease
A summary of the management of thalassemias with emphasis on the management of anemia with transfusion support, iron overload, medications such as luspatercept, and advanced treatments such as stem cell and gene therapy
An overview of thalassemias including their definition, classification, and description of the most common thalassemias. We hope to help you understand the differences between alpha and beta thalassemias better!
